John B. Penney, Jr. Professor of Neurology, Harvard Medical School
Lab Phone: 617-726-2299
Brad Hyman studies the anatomical and molecular basis of dementia in Alzheimer’s disease, and Dementia with Lewy Bodies. His research includes a collaborative of several labs working on different aspects of neurodegenerative disease and dementia. He also has a clinical practice in the Memory and Disorder Unit at the Massachusetts General Hospital devoted towards the care of patients with dementia. His research laboratory is pursuing research in Alzheimer’s disease, and other neurodegenerative diseases, with a goal of understanding the neuropathophysiologic and genetic factors that underlie dementia.
They are developing methods to examine clinical-pathological correlates and biomarkers in Alzheimer’s, as well as animal and cell models to explore the natural history of the diseases. A recent focus has been the use of advanced microscopy methods – including multiphoton microscopy for in vivo imaging of plaques, tangles, and synuclein aggregates, as well as FRET methods to detect protein-protein interactions and protein conformation.
Brad is the John B. Penney, Jr. Professor of Neurology at Harvard Medical School and Massachusetts General Hospital. He directs the Alzheimer's disease research unit at the Massachusetts General Institute for Neurodegenerative Diseases (MIND). Brad received his M.D. and Ph.D. from University of Iowa and has received the Metropolitan Life Award, the Potamkin Prize, a National Institute on Aging Merit award, and an Alzheimer Association Pioneer Award. He is the current Director of the Massachusetts Alzheimer's Disease Research Center.